Introduction to Hair Follicle Regeneration
Claire Higgins, PhD, a leading researcher at Imperial College London, heads the Skin Regeneration Laboratory in the United Kingdom, focusing on skin and hair follicle regeneration. Her team, consisting of four postdoctoral researchers and seven PhD students, explores ways to restore the original form and function of tissues affected by disease or injury. The primary goal is to promote true regeneration rather than scar tissue formation, which can impair tissue function.
Also Read: Stem Cell Therapy, PRP, and Genetics for Hair Regrowth
Research on Hair Loss
A significant question surrounding hair loss is whether a definitive cure exists. Dr. Higgins believes that a cure will eventually be found, although she cannot predict when. Current research primarily focuses on identifying therapeutics that target the hair follicle cycle. However, many existing treatments are reactive rather than proactive, often addressing issues after they arise. She emphasizes the importance of understanding the dynamics of hair loss to identify effective treatments, which may include cell therapies or a combination of various approaches.
Genetics of Hair Loss
Dr. Higgins addresses the genetic components of androgenetic alopecia, a common form of hair loss. While there is a genetic aspect, it is not inherited in a straightforward manner. The complexity arises because no single gene has been identified as the sole cause; instead, variations in multiple genes contribute to the condition. The role of the androgen receptor has been noted, particularly in male pattern hair loss, but its connection to female pattern hair loss remains unclear. Understanding these genetic variations is crucial for developing targeted treatments for both men and women.
The Mechanism of Hair Loss
Delving into the biological aspects, Dr. Higgins explains that hair loss involves miniaturization, where hair follicles shrink rather than disappear entirely. This process results in smaller hair fibers produced by the follicles. Interestingly, her lab’s research has shifted the perspective on androgenetic alopecia, suggesting that the disease may not solely be driven by androgens but may also involve a loss of protective factors in genetically predisposed areas of the scalp.
Research Collaborations and Findings
In collaboration with the Farjo Clinic, Dr. Higgins’s lab has isolated hair follicles from different scalp regions to investigate the genetic factors influencing miniaturization. While initial analyses did not identify specific drivers of miniaturization in the frontal scalp, they found protective elements in the occipital scalp. This research highlights the complexity of hair loss patterns and the necessity for a multifaceted approach to treatment.
Conclusion
Dr. Higgins’s passion for hair follicle research stems from her academic background and the inspiration of influential mentors. Her ongoing work not only aims to unravel the complexities of hair loss but also contributes significantly to the field of regenerative medicine, showcasing the interconnectedness of various biological processes.